Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.55 |
| ▸ | MAOB | P27338 | 5/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TFEB | P19484 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536304 | 0.84 | HTT (0.61) | BCHEMAPTKDM4EHTTNPC1 | |
| SCHEMBL7150278 | 0.79 | MAPT (0.56) | MAOBNR1H4BCHEMAPTALDH1A1 | |
| SCHEMBL4535102 | 0.78 | AR (0.80) | ARMAOBNR1H4ABCG2BCHE | |
| SCHEMBL10861605 | 0.74 | KDM4E (0.53) | MAPTKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL15631497 | 0.74 | ABCG2 (0.68) | ARMAOBNR1H4ABCG2BCHE | |
| SCHEMBL29032542 | 0.73 | NFE2L2 (0.39) | BCHEMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL10699258 | 0.73 | ALDH1A1 (0.44) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL11848066 | 0.73 | LMNA (0.51) | MAPTKDM4EALDH1A1HPGDHTT | |
| SCHEMBL10614570 | 0.71 | NFE2L2 (0.59) | MAOBNFE2L2CYP1A1CYP1B1 | |
| SCHEMBL10614563 | 0.71 | NFE2L2 (0.59) | MAOBNFE2L2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653497-B1 | Reacting dihydroxychalcone with cyanogen chloride or bromide and triethylamine; chemical intermediates | LONZA AG (CH) | 2003-11-25 | — | — | US | claimed |
| EP-1202958-B1 | DICYANATOCHALCONES AND METHOD FOR THE PRODUCTION THEREOF | LONZA AG (CH) | 2003-10-22 | — | — | EP | claimed |
| US-6653497-B1 | Reacting dihydroxychalcone with cyanogen chloride or bromide and triethylamine; chemical intermediates | LONZA AG (CH) | 2003-11-25 | — | — | US | disclosed |
| US-6653497-B1 | Reacting dihydroxychalcone with cyanogen chloride or bromide and triethylamine; chemical intermediates | LONZA AG (CH) | 2003-11-25 | — | — | US | disclosed |
| EP-1202958-B1 | DICYANATOCHALCONES AND METHOD FOR THE PRODUCTION THEREOF | LONZA AG (CH) | 2003-10-22 | — | — | EP | disclosed |
| EP-1202958-A1 | DICYANATOCHALCONES AND METHOD FOR THE PRODUCTION THEREOF | Lonza AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010824-A1 | DICYANATOCHALCONES AND METHOD FOR THE PRODUCTION THEREOF | LONZA AG (CH) | 2001-02-15 | — | — | WO | disclosed |