Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579475 | 0.86 | GNE (0.55) | IRAK4HPGDGNETSHRSMN1; SMN2 | |
| SCHEMBL5237 | 0.85 | GNE (0.68) | HPGDGNESMN1; SMN2NPC1RAB9A | |
| SCHEMBL2532948 | 0.84 | GNE (0.66) | HPGDGNETSHRSMN1; SMN2NPC1 | |
| SCHEMBL2966899 | 0.84 | HRH3 (0.51) | GNESMN1; SMN2HRH3USP2MAPK1 | |
| SCHEMBL2590496 | 0.82 | HSD11B1 (0.60) | HPGDGNETSHRSMN1; SMN2NPC1 | |
| SCHEMBL3759078 | 0.82 | GNE (0.48) | IRAK4HPGDGNETSHRSMN1; SMN2 | |
| SCHEMBL31395167 | 0.81 | HRH4 (0.53) | HPGDGNETSHRHRH4SMN1; SMN2 | |
| SCHEMBL1554586 | 0.81 | RAB9A (0.50) | HPGDGNESMN1; SMN2NPC1RAB9A | |
| SCHEMBL2594231 | 0.81 | GNE (0.50) | IRAK4HPGDGNETSHRSMN1; SMN2 | |
| SCHEMBL30911663 | 0.81 | RAB9A (0.50) | HPGDGNESMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11939301-B2 | 5HT1F receptor agonists and mitochondrial biogenesis | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2024-03-26 | — | — | US | disclosed |
| US-20210238147-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2021-08-05 | — | — | US | disclosed |
| US-20210238147-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2021-08-05 | — | — | US | disclosed |
| US-11014892-B2 | 5HT1F receptor agonists and mitochondrial biogenesis | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2021-05-25 | — | — | US | disclosed |
| US-11014892-B2 | 5HT1F receptor agonists and mitochondrial biogenesis | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200055827-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2020-02-20 | — | — | US | disclosed |
| US-20200055827-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2020-02-20 | — | — | US | disclosed |
| US-9624182-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9624182-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9624182-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9090573-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090573-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090573-B2 | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20120289522-A1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289522-A1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289522-A1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC. | 2012-11-15 | — | — | US | disclosed |
| CN-102639515-A | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-08-15 | — | — | CN | disclosed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11939301-B2 | 5HT1F receptor agonists and mitochondrial biogenesis | HTR1F, HTR1A, TFAM | IRAK4 3358/4885HPGD 1071/4885GNE 4792/4885 |
| US-11014892-B2 | 5HT1F receptor agonists and mitochondrial biogenesis | HTR1F, HTR1A, TFAM | IRAK4 3358/4885HPGD 1071/4885GNE 4792/4885 |
| US-20120289522-A1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR4 | IRAK4 1085/4885HPGD 1947/4885GNE 1866/4885 |
| US-20200055827-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | HTR1F, HTR1A, TFAM | IRAK4 3358/4885HPGD 1071/4885GNE 4792/4885 |
| US-20210238147-A1 | 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS | HTR1F, HTR1A, TFAM | IRAK4 3358/4885HPGD 1071/4885GNE 4792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.