SCHEMBL716420

SCHEMBL716420

Oc1cc(CCc2ccccc2)cc(O)c1O

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 1/20 0.55
ALOX15 P16050 1/20 0.55
DAO P14920 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
POLB P06746 1/20 0.50
BCL2 P10415 2/20 0.49
BCL2L1 Q07817 2/20 0.49
MCL1 Q07820 1/20 0.49
BCL2A1 Q16548 1/20 0.49
IDH1 O75874 1/20 0.48
CYP2A6 P11509 1/20 0.48
HTR2A P28223 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TAAR1 Q96RJ0 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stilbostemin B SCHEMBL31039665 0.82 IGF1R (0.52) IGF1RALOX15DAOBCL2BCL2L1
SCHEMBL716875 0.81 ESR1 (0.67) IGF1RALOX15L3MBTL1POLBTAAR1
SCHEMBL278794 0.81 IDH1 (0.65) IGF1RALOX15BCL2BCL2L1IDH1
SCHEMBL13903972 0.79 TDP1 (0.46) IGF1RALOX15DAOBCL2BCL2L1
SCHEMBL9744485 0.79 ALOX15 (0.84) IGF1RALOX15IDH1TAAR1TDP1
SCHEMBL4648373 0.79 ALDH1A1 (0.58) ALOX15CYP2A6HTR2ASMN1; SMN2TAAR1
Hydrogen Peroxide SCHEMBL10839871 0.79 TDP1 (0.71) ALOX15CYP2A6HTR2ASMN1; SMN2TAAR1
Hydrogen Peroxide SCHEMBL10839772 0.79 TDP1 (0.71) ALOX15CYP2A6HTR2ASMN1; SMN2TAAR1
SCHEMBL22149262 0.79 GAA (0.56) IGF1RALOX15DAOBCL2L1MCL1
SCHEMBL31540969 0.79 IGF1R (0.53) IGF1RALOX15DAOBCL2BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12410116-B2 Compounds and use thereof in methods of treatment THE UNIVERSITY OF QUEENSLAND (AU) 2025-09-09 US disclosed
US-20240002326-A1 COMPOUNDS AND USE THEREOF IN METHODS OF TREATMENT THE UNIVERSITY OF QUEENSLAND (AU) 2024-01-04 US disclosed
US-20230100768-A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS AND/OR LYMPHANGIOGENESIS-RELATED DISEASES THE UNIVERSITY OF QUEENSLAND (AU) 2023-03-30 US disclosed
US-11434190-B2 Inhibitors of SOX18 protein activity for treating angiogenesis-and/or lymphangiogenesis-related diseases THE UNIVERSITY OF QUEENSLAND (AU) 2022-09-06 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20190337880-A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES THE UNIVERSITY OF QUEENSLAND (AU) 2019-11-07 US disclosed
US-20190337880-A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES THE UNIVERSITY OF QUEENSLAND (AU) 2019-11-07 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
EP-2391658-A1 MOLECULARLY IMPRINTED POLYMERS Commonwealth Scientific and Industrial Research Organisation (AU) 2011-12-07 EP disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed
US-5087548-A POSITIVE TYPE RADIATION-SENSITIVE RESIN COMPOSITION JAPAN SYNTHETIC RUBBER CO., INC. (JP) 1992-02-11 US disclosed
EP-0227487-A2 Positive type radiation-sensitive resin composition JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1987-07-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190337880-A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES SOX18, PROX1, RUNX1 IGF1R 2251/4885ALOX15 2078/4885DAO 3710/4885
US-11434190-B2 Inhibitors of SOX18 protein activity for treating angiogenesis-and/or lymphangiogenesis-related diseases SOX18, PROX1, RUNX1 IGF1R 2251/4885ALOX15 2078/4885DAO 3710/4885
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 IGF1R 147/4885ALOX15 2317/4885DAO 2708/4885
US-20230100768-A1 INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS AND/OR LYMPHANGIOGENESIS-RELATED DISEASES SOX18, PROX1, RUNX1 IGF1R 2504/4885ALOX15 1764/4885DAO 3586/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 IGF1R 147/4885ALOX15 2317/4885DAO 2708/4885
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 IGF1R 147/4885ALOX15 2317/4885DAO 2708/4885
US-12410116-B2 Compounds and use thereof in methods of treatment SOX18, PROX1, RUNX1 IGF1R 2869/4885ALOX15 2048/4885DAO 3538/4885
US-20240002326-A1 COMPOUNDS AND USE THEREOF IN METHODS OF TREATMENT SOX18, PROX1, RUNX1 IGF1R 2869/4885ALOX15 2048/4885DAO 3538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.