SCHEMBL7170686

SCHEMBL7170686

CCSc1ccc(C(=O)Nc2cccc3cc(C(=O)Nc4ccc(Br)cc4-c4nnn[nH]4)[nH]c23)cc1.CS(=O)(=O)c1ccccc1C(=O)Nc1cccc2cc(C(=O)Nc3ccc(Br)cc3-c3nnn[nH]3)[nH]c12.O=C(Nc1ccc(Br)cc1-c1nnn[nH]1)c1cc2cccc(NC(=O)c3ccccc3-c3ccccc3)c2[nH]1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
F10 P00742 4/20 0.35
KLK1 P06870 1/20 0.35
PTGFR P43088 1/20 0.33
NPSR1 Q6W5P4 2/20 0.33
HIF1A Q16665 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
POLB P06746 2/20 0.33
LMNA P02545 1/20 0.33
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA4 P43681 1/20 0.32
HTT P42858 1/20 0.32
PTGES O14684 1/20 0.32
PPARG P37231 1/20 0.32
PPARD Q03181 1/20 0.32
PPARA Q07869 1/20 0.32
NR1H4 Q96RI1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6707728 0.88 PABPC1 (0.39) F10KLK1NPSR1HIF1ARXFP1
SCHEMBL6711714 0.87 GPR35 (0.39) ALDH1A1NPSR1HIF1ARXFP1POLB
SCHEMBL6712183 0.85 ALDH1A1 (0.47) ALDH1A1NPSR1HIF1ARXFP1POLB
SCHEMBL6711851 0.81 PTGES (0.40) F10POLBPTGES
SCHEMBL6711741 0.80 HIF1A (0.47) NPSR1HIF1ARXFP1
SCHEMBL6714040 0.79 F10 (0.38) ALDH1A1F10POLBLMNA
SCHEMBL6710319 0.78 CHRNB2 (0.43) F10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL6713465 0.78 GPR35 (0.43) NPSR1HIF1ARXFP1
SCHEMBL6709834 0.78 MAPT (0.40) ALDH1A1NPSR1HIF1ARXFP1POLB
SCHEMBL6709845 0.78 NR1H4 (0.39) RXFP1POLBPTGESNR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed