Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28135252 | 0.91 | ADORA2A (0.52) | POLBCASP3SENP7SENP6ADORA2A | |
| SCHEMBL13295147 | 0.84 | HPGDS (0.48) | ADORA2AAURKAHSP90AA1PRKACAMEN1 | |
| SCHEMBL10942017 | 0.78 | MAPK14 (0.39) | POLBCASP3SENP7SENP6L3MBTL1 | |
| SCHEMBL9130502 | 0.78 | RAB9A (0.44) | POLBCASP3SENP7SENP6ADORA2A | |
| SCHEMBL24165357 | 0.77 | POLB (0.44) | POLBCASP3SENP7SENP6ADORA2A | |
| SCHEMBL16526833 | 0.76 | TGFBR1 (0.44) | POLBADORA1ADORA3ADORA2BTDP1 | |
| SCHEMBL16526759 | 0.75 | CYP11B2 (0.42) | CAMKK2CAMKK1ALOX5APFEN1 | |
| SCHEMBL9126504 | 0.75 | MEN1 (0.46) | ADORA2AAURKAHSP90AA1PRKACAL3MBTL1 | |
| SCHEMBL28060947 | 0.75 | MEN1 (0.50) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL21368660 | 0.74 | KDM4E (0.50) | POLBCASP3SENP7SENP6ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104011-B1 | PYRIMIDINE DERIVATIVES | Chisso Corporation (JP) | 1986-04-23 | — | — | EP | claimed |
| EP-0104011-A1 | Pyrimidine derivatives | Chisso Corporation (JP) | 1984-03-28 | — | — | EP | claimed |
| CN-107141295-A | A kind of simple synthesis of uracil derivative | 重庆文理学院 | 2017-09-08 | — | — | CN | disclosed |
| US-6511720-B2 | 1-(triethoxysilane)-4-(4-(4-propylcyclohexyl)phenyl)butane for example; used to produce homeotropic alignment of liquid-crystalline phases on surfaces | MERCK PATENT GESELLESCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2003-01-28 | — | — | US | disclosed |