Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | B3GNT2 | Q9NY97 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187300 | 0.80 | PDE4B (0.48) | PDE4BLMNAMEN1KMT2A | |
| SCHEMBL7186419 | 0.80 | ALDH1A1 (0.48) | B3GNT2POLBMEN1KMT2A | |
| SCHEMBL7456189 | 0.78 | B3GNT2 (0.43) | B3GNT2KDM4EMEN1KMT2A | |
| SCHEMBL7184379 | 0.77 | PDE4B (0.38) | PDE4BB3GNT2LMNAPOLBKDM4E | |
| SCHEMBL7456604 | 0.76 | PDE4B (0.40) | PDE4BB3GNT2LMNAPOLBKCNH2 | |
| SCHEMBL16593900 | 0.71 | MEN1 (0.61) | PDE4BLMNAPOLBKDM4EMAPK1 | |
| SCHEMBL7180238 | 0.69 | HSD11B1 (0.39) | PDE4BKDM4EMEN1KMT2A | |
| SCHEMBL7180232 | 0.69 | HSD11B1 (0.39) | PDE4BKDM4EMEN1KMT2A | |
| SCHEMBL7187351 | 0.65 | PGR (0.38) | PDE4BPOLB | |
| SCHEMBL7178509 | 0.65 | PGR (0.38) | PDE4BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |