Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170637 | 0.91 | ALOX15 (0.45) | MMP8ALOX15HSD17B10SMN1; SMN2MMP1 | |
| SCHEMBL7306891 | 0.90 | ALDH1A1 (0.43) | MMP8ALOX15HSD17B10SMN1; SMN2ADAM17 | |
| SCHEMBL7174032 | 0.84 | ADAM17 (0.50) | MMP8ADAM17MMP1FCER2CNR1 | |
| SCHEMBL7185090 | 0.83 | MMP8 (0.55) | MMP8ALOX15HSD17B10SMN1; SMN2MMP1 | |
| SCHEMBL7172650 | 0.83 | NPC1 (0.47) | SMN1; SMN2MMP1MAPTKDM4ENPC1 | |
| SCHEMBL7173680 | 0.82 | ALDH1A1 (0.41) | MMP8ALOX15HSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL7178370 | 0.81 | PPARG (0.46) | SMN1; SMN2MMP1KDM4ENPC1RAB9A | |
| SCHEMBL7192046 | 0.77 | MMP3 (0.52) | ADAM17MMP1NPC1RAB9AKMT2A | |
| SCHEMBL7174719 | 0.76 | NPC1 (0.45) | SMN1; SMN2MMP1MAPTKDM4ENPC1 | |
| SCHEMBL7177458 | 0.75 | MMP8 (0.52) | MMP8MMP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |