Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.45 |
| ▸ | FEN1 | P39748 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA9 | Q16790 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179095 | 0.83 | FEN1 (0.41) | ALOX5APFEN1ALDH1A1 | |
| SCHEMBL7178906 | 0.80 | NSD2 (0.45) | ALOX5APFEN1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5030908 | 0.77 | HSD11B1 (0.40) | ALOX5APFEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7179227 | 0.77 | ALOX5AP (0.52) | ALOX5APFEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL483343 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EBRD4CA12CA9 | |
| SCHEMBL8510774 | 0.74 | TTR (0.38) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9108107 | 0.72 | ALOX5AP (0.56) | ALOX5APFEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL3435329 | 0.71 | HTR6 (0.46) | ALOX5APFEN1ALDH1A1KDM4E | |
| SCHEMBL11813345 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDBRD4 | |
| SCHEMBL7176660 | 0.71 | FEN1 (0.55) | ALOX5APFEN1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | disclosed |