Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.47 |
| ▸ | FOS | P01100 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7193665 | 0.95 | THRB (0.58) | KMT2ATHRATHRBMTNR1AMTNR1B | |
| SCHEMBL7194180 | 0.93 | THRA (0.62) | KMT2ATHRATHRBLTB4RNR1H4 | |
| SCHEMBL7189188 | 0.92 | THRA (0.64) | KMT2ATHRATHRBLTB4RNR1H4 | |
| SCHEMBL7196312 | 0.91 | KMT2A (0.52) | KMT2ATHRATHRBMTNR1AMTNR1B | |
| SCHEMBL7198598 | 0.87 | THRB (0.53) | KMT2ATHRATHRBLTB4RFOS | |
| SCHEMBL7192819 | 0.87 | FOS (0.49) | KMT2ATHRATHRBMTNR1AMTNR1B | |
| SCHEMBL7193935 | 0.84 | THRA (0.57) | KMT2ATHRATHRBLTB4RNR1H4 | |
| SCHEMBL7198565 | 0.83 | THRA (0.59) | KMT2ATHRATHRBLTB4RNR1H4 | |
| SCHEMBL7198034 | 0.82 | MTNR1A (0.50) | KMT2AMTNR1AMTNR1BL3MBTL1ABCB1 | |
| SCHEMBL7191853 | 0.82 | KMT2A (0.51) | KMT2ATHRATHRBL3MBTL1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | STATENS SERUM INSTITUTE (DK) | 2003-04-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | AKR1C3, AKR1C1, AKR1A1 | KMT2A 4485/4885THRA 2660/4885THRB 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.