Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226509 | 0.85 | TSHR (0.36) | TSHRCYP1A1CYP1B1 | |
| SCHEMBL13982141 | 0.82 | RAPGEF4 (0.33) | TSHRCYP1A1CYP1B1HDAC8 | |
| SCHEMBL15094220 | 0.82 | RAPGEF4 (0.32) | TSHRCYP1A1CYP1B1 | |
| SCHEMBL4391765 | 0.82 | GRM5 (0.37) | — | |
| SCHEMBL7034739 | 0.82 | HCAR1 (0.40) | TSHRCYP3A4CYP1A1CYP1B1ALDH1A1 | |
| SCHEMBL8486211 | 0.82 | CYP3A4 (0.55) | TSHRCYP3A4TP53CYP1A1CYP1B1 | |
| SCHEMBL11230096 | 0.82 | TSHR (0.33) | TSHR | |
| SCHEMBL11237065 | 0.80 | GAA (0.35) | TSHRALDH1A1 | |
| SCHEMBL24216635 | 0.77 | HSD17B10 (0.38) | ALDH1A1HSD17B10 | |
| SCHEMBL30460212 | 0.77 | HSD17B10 (0.38) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808071-A | Method for synthesizing polysubstituted aminoisoquinoline compound by cyclization of pyridine and alkyne under catalysis of rhodium | 中国科学院兰州化学物理研究所 | 2020-10-23 | — | — | CN | claimed |
| EP-2861566-B1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | HOFFMANN LA ROCHE (CH) | 2016-12-21 | — | — | EP | claimed |
| EP-1664027-B1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2009-12-30 | — | — | EP | claimed |
| EP-1664023-B1 | SUSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2008-08-13 | — | — | EP | claimed |
| EP-1310487-B1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI SEIYAKU CO (JP) | 2007-01-03 | — | — | EP | claimed |
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | claimed |
| US-20250115630-A1 | METAL COMPLEXES | UDC IRELAND LTD (IE) | 2025-04-10 | — | — | US | disclosed |
| US-12180233-B2 | Metal complexes | UDC IRELAND LIMITED (IE) | 2024-12-31 | — | — | US | disclosed |
| CN-111699192-B | Metal complex | UDC爱尔兰有限公司 | 2024-03-08 | — | — | CN | disclosed |
| EP-3752512-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2023-03-01 | — | — | EP | disclosed |
| US-20220289778-A1 | METAL COMPLEXES | UDC IRELAND LIMITED (IE) | 2022-09-15 | — | — | US | disclosed |
| CN-111808071-B | Method for synthesizing polysubstituted aminoisoquinoline compound by cyclization of pyridine and alkyne under catalysis of rhodium | 中国科学院兰州化学物理研究所 | 2022-03-25 | — | — | CN | disclosed |
| EP-3752512-A1 | METAL COMPLEXES | Merck Patent GmbH (DE) | 2020-12-23 | — | — | EP | disclosed |
| EP-0171209-B1 | ACETYLENIC PHENOXYPROPANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION | McNeilab, Inc. (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4742084-A | Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives | MCNEILAB, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4661635-A | ANTIARRHYTHMIA AGENTS | MCNEILAB, INC. (US) | 1987-04-28 | — | — | US | disclosed |
| US-4652584-A | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension | MCNEILAB, INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0171209-A1 | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension | McNeilab, Inc. (US) | 1986-02-12 | — | — | EP | disclosed |
| EP-0146271-A2 | Aralykyl (arylethynyl) aralkyl amines for use as vasodilators and antihypertensives | McNeilab, Inc. (US) | 1985-06-26 | — | — | EP | disclosed |
| EP-0145361-A2 | Acetylene derivatives for the treatment of hypertension and angina | McNeilab, Inc. (US) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12180233-B2 | Metal complexes | IMMT, MCU, SOD1 | TSHR 3493/4885CYP3A4 2260/4885TP53 3881/4885 |
| US-20250115630-A1 | METAL COMPLEXES | IMMT, MCU, SOD1 | TSHR 3493/4885CYP3A4 2260/4885TP53 3881/4885 |
| US-20220289778-A1 | METAL COMPLEXES | IMMT, MCU, SOD1 | TSHR 3493/4885CYP3A4 2260/4885TP53 3881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.