⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12200280 | 0.84 | ALDH1A1 (0.39) | — | |
| SCHEMBL5472705 | 0.79 | — | — | |
| SCHEMBL5472838 | 0.78 | ROCK2 (0.30) | — | |
| SCHEMBL5477265 | 0.78 | MAPT (0.31) | — | |
| SCHEMBL27500355 | 0.78 | OPRM1 (0.31) | — | |
| SCHEMBL2724523 | 0.77 | NPSR1 (0.46) | — | |
| SCHEMBL3120599 | 0.77 | GAA (0.40) | — | |
| SCHEMBL27825318 | 0.76 | — | — | |
| SCHEMBL486173 | 0.76 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL7641419 | 0.76 | RAB9A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1346351-A | 1,2-benzothiazepines for the treatment of hyperlipidemic diseases | SEARLE & CO (US) | 2002-04-24 | — | — | CN | claimed |
| EP-0095640-B1 | ALKYLENE-BRIDGED GUANIDINO-THIAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | BAYER AG (DE) | 1986-01-29 | — | — | EP | claimed |
| CN-101998853-B | Thienopyridone derivatives as AMP-activated protein kinase (AMPK) activators | MERCK PATENT GMBH | 2015-02-11 | — | — | CN | disclosed |
| CN-103951649-A | Heterocycle substituted hydroxamate aromatic amide compound or pharmaceutical acceptable salt thereof, and preparation method and application thereof | UNIV EAST CHINA NORMAL | 2014-07-30 | — | — | CN | disclosed |
| CN-102015676-B | Thienopyridone derivatives as AMP-activated protein kinase (AMPK) activators | MERCK PATENT GMBH | 2014-05-28 | — | — | CN | disclosed |
| CN-1195748-C | 1,2-benzothiazepines for the treatment of hyperlipidemic diseases | SEARLE & CO (US) | 2005-04-06 | — | — | CN | disclosed |
| US-6566355-B1 | Useful in combination with beta -lactam antibiotics in the control of beta -lactamase forming pathogens | HOFFMANN-LA ROCHE INC. | 2003-05-20 | — | — | US | disclosed |
| CN-1346351-A | 1,2-benzothiazepines for the treatment of hyperlipidemic diseases | SEARLE & CO (US) | 2002-04-24 | — | — | CN | disclosed |
| US-6218379-B1 | Tricyclic carbacephems | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-0912574-A1 | BETA-LACTAMS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5712268-A | Compositions of tricyclic β-lactams and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 1998-01-27 | — | — | US | disclosed |
| US-5698577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |
| WO-1997045429-A1 | BETA-LACTAMS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-04 | — | — | WO | disclosed |
| EP-0508234-B1 | Beta-lactames | HOFFMANN LA ROCHE (CH) | 1996-07-24 | — | — | EP | disclosed |
| US-5510343-A | BETA-LACTAMASE INHIBITOR | HOFFMANN-LA ROCHE INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5494666-A | BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5464617-A | 1H-2,6a-diazacyclobut(cd)indene-6-carboxylic acid derivatives, antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0671401-A1 | Beta lactames | F. HOFFMANN-LA ROCHE AG (CH) | 1995-09-13 | — | — | EP | disclosed |
| EP-0508234-A2 | Beta-lactames | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-14 | — | — | EP | disclosed |
| CN-1062730-A | n-acyl-2, 3-benzodiazepine derivatives, pharmaceutical compositions and process for their preparation | CYOGYSZERKUTATO INTEZET K V (HU) | 1992-07-15 | — | — | CN | disclosed |