Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 7/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158804 | 0.90 | CCR5 (0.30) | CCR5LMNA | |
| SCHEMBL4873613 | 0.86 | LMNA (0.31) | LMNA | |
| SCHEMBL4871446 | 0.86 | CCR5 (0.35) | PKMALDH1A1GAACCR5KCNH2 | |
| SCHEMBL4874473 | 0.86 | MAOB (0.34) | ALDH1A1GAAACHERORCSIGMAR1 | |
| SCHEMBL7200638 | 0.86 | TSHR (0.34) | PKMALDH1A1GAACCR5KCNH2 | |
| SCHEMBL4875121 | 0.86 | CYP2D6 (0.36) | PKMALDH1A1GAACCR5KCNH2 | |
| SCHEMBL4874460 | 0.85 | ACHE (0.33) | PKMALDH1A1GAACCR5ACHE | |
| SCHEMBL7089594 | 0.85 | — | — | |
| SCHEMBL7085856 | 0.85 | ADAMTS5 (0.33) | CCR5ADAMTS5 | |
| SCHEMBL4870439 | 0.84 | LMNA (0.31) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |