Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formamide SCHEMBL7067260 | 0.90 | USP2 (0.36) | PIK3CGUSP2JAK2JAK3SMPD3 | |
| SCHEMBL15020746 | 0.84 | PIK3CG (0.41) | PIK3CGJAK2JAK3SMPD3AXL | |
| SCHEMBL9741997 | 0.74 | ALDH1A1 (0.38) | HPGDALDH1A1APOBEC3A | |
| Ammonia Solution, Strong SCHEMBL6629978 | 0.72 | HDAC1 (0.41) | USP2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15308545 | 0.71 | PIK3CG (0.54) | PIK3CGJAK2JAK3SMPD3AXL | |
| SCHEMBL18622279 | 0.71 | PIK3CG (0.46) | PIK3CGJAK2JAK3SMPD3AXL | |
| SCHEMBL38666729 | 0.70 | SMPD3 (0.43) | PIK3CGJAK2JAK3SMPD3AXL | |
| SCHEMBL16646749 | 0.70 | JAK2 (0.46) | PIK3CGJAK2JAK3SMPD3PDE2A | |
| SCHEMBL25317207 | 0.67 | NOS2 (0.42) | USP2PDE10APDE4APDE4BPDE4C | |
| SCHEMBL30410343 | 0.66 | SMN1; SMN2 (0.41) | PIK3CGJAK2JAK3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010041673-A1 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | PFIZER INC. | 2001-11-15 | — | — | US | claimed |
| US-6589947-B1 | Treatment or prevention of Syndrome X in an animal, preferably a mammal including a human subject or a companion animal, using a corticotropin releasing factor (CRF) antagonist alone or together with a glucocorticoid receptor antagonist. | PFIZER INC. | 2003-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041673-A1 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | CRH, GHSR, GHRHR | PIK3CG 3857/4885USP2 1006/4885JAK2 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.