Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206870 | 0.86 | SRD5A2 (0.39) | GLRA1SRD5A2SOAT2MYCSOAT1 | |
| SCHEMBL7206347 | 0.78 | GABRA1 (0.43) | SCN5ASCN9ASCN10ASOAT2MYC | |
| SCHEMBL7206954 | 0.77 | SRD5A2 (0.34) | GLRA1SRD5A2SCN5ASCN9ASCN10A | |
| SCHEMBL9474040 | 0.74 | KMT2A (0.55) | GLRA1SRD5A2 | |
| SCHEMBL9474053 | 0.72 | SCN5A (0.41) | GLRA1SCN5ASCN9ASCN10A | |
| SCHEMBL15517637 | 0.71 | NLRP3 (0.46) | — | |
| SCHEMBL15517271 | 0.69 | OGG1 (0.48) | — | |
| SCHEMBL9472848 | 0.69 | NLRP3 (0.61) | SCN5ASCN9ASCN10A | |
| SCHEMBL7212859 | 0.69 | AKR1B1 (0.45) | — | |
| SCHEMBL7206379 | 0.68 | LMNA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |
| US-5633287-A | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents | WARNER-LAMBERT COMPANY (US) | 1997-05-27 | — | — | US | disclosed |