Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701445 | 0.80 | HSD17B10 (0.56) | NPC1LMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL7207810 | 0.78 | SMN1; SMN2 (0.41) | NPC1LMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL7212823 | 0.77 | L3MBTL1 (0.50) | NPC1HTTRAB9ACYP3A4CYP2D6 | |
| SCHEMBL7206347 | 0.72 | GABRA1 (0.43) | LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL32679613 | 0.72 | MEN1 (0.48) | NPC1LMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL32679611 | 0.72 | MEN1 (0.48) | NPC1LMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL4573904 | 0.71 | ALDH1A1 (0.48) | CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1599400 | 0.70 | HSD17B10 (0.56) | LMNASMN1; SMN2CYP3A4PTPN1USP2 | |
| SCHEMBL29043392 | 0.69 | PTPN1 (0.45) | SMN1; SMN2CYP3A4PTPN1USP2MAPK1 | |
| SCHEMBL6201398 | 0.69 | PTPN1 (0.45) | NPC1LMNAHTTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |