Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984307 | 0.79 | MGAM (0.49) | GAAALDH1A1HPGDTDP1MGAM | |
| SCHEMBL7208967 | 0.78 | ADORA1 (0.52) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL215756 | 0.76 | NUDT1 (0.70) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL66295 | 0.75 | PSMB8 (0.59) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL1170768 | 0.75 | ADORA1 (0.61) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL6982057 | 0.75 | CNR2 (0.48) | ADORA1MAOBADORA2AADORA2BNUDT1 | |
| SCHEMBL6973496 | 0.75 | RIPK1 (0.41) | ADORA1MAOBADORA2AADORA2BGAA | |
| SCHEMBL13238087 | 0.74 | ADORA1 (0.49) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL11850373 | 0.73 | ADORA2A (0.65) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL13238089 | 0.72 | ADORA1 (0.47) | ADORA1MAOBADORA2AADORA2BPSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220380341-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-12-01 | — | — | US | disclosed |
| WO-2020081856-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220380341-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | NAT1, CXCR4, HAX1 | ADORA1 2208/4885MAOB 852/4885ADORA2A 3470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.