SCHEMBL7214035

SCHEMBL7214035

CC(c1ccc(Cl)cc1)C1NC(C)(C(C)C)C(=O)O1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
BRD4 O60885 1/20 0.35
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
ADRB2 P07550 1/20 0.33
HSD11B1 P28845 4/20 0.32
RECQL P46063 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PGR P06401 1/20 0.31
GRM2 Q14416 1/20 0.30
CSF1R P07333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7213565 0.84 SLC6A4 (0.43) SLC6A2SLC6A4SLC6A3BRD4LMNA
SCHEMBL7219129 0.66 SMN1; SMN2 (0.35) SLC6A3GAAKMT2AHSD11B1RECQL
SCHEMBL7214177 0.64 CA2 (0.41) LMNAHSD11B1ALDH1A1
SCHEMBL9017824 0.61 SLC6A2 (0.42) SLC6A2SLC6A4SLC6A3BRD4GAA
SCHEMBL7213677 0.60 GRM2 (0.38) SLC6A2SLC6A4SLC6A3LMNAGAA
SCHEMBL435756 0.58 SLC6A4 (0.53) SLC6A2SLC6A4SLC6A3LMNAGAA
SCHEMBL197810 0.57 ADRB2 (0.65) SLC6A2SLC6A3BRD4LMNAKMT2A
SCHEMBL1045498 0.56 ADRB2 (0.56) SLC6A2SLC6A3BRD4LMNAGAA
SCHEMBL12591826 0.56 ADRB2 (0.56) LMNAKMT2AADRB2NPSR1
SCHEMBL21254366 0.55 BCL2A1 (0.49) SLC6A2SLC6A4SLC6A3GAAADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6504046-B1 Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-01-07 US disclosed
US-6469210-B1 EXCELLENT FUNGICIDAL ACTIVITY IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-22 US disclosed
EP-1092705-A1 PROCESS FOR THE PREPARATION OF AMIDES IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed
EP-1092706-A1 PROCESS FOR THE PREPARATION OF PHENYLALKANOIC ACID AMIDES AND INTERMEDIATES THEREFOR IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed