Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.38 |
| ▸ | MMP3 | P08254 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 7/20 | 0.35 |
| ▸ | MMP8 | P22894 | 5/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078051 | 0.91 | MMP2 (0.30) | MMP13MMP3MMP2MMP9 | |
| SCHEMBL7077475 | 0.88 | — | — | |
| SCHEMBL7075518 | 0.78 | — | — | |
| SCHEMBL7080806 | 0.76 | MMP3 (0.51) | MMP13MMP3MMP2MMP9MMP1 | |
| SCHEMBL7077674 | 0.76 | MMP13 (0.44) | MMP13MMP3MMP2MMP9MMP1 | |
| SCHEMBL6948783 | 0.74 | MMP13 (0.47) | MMP13MMP3MMP2MMP9MMP1 | |
| SCHEMBL7074693 | 0.74 | — | — | |
| SCHEMBL7073721 | 0.72 | — | — | |
| SCHEMBL7077657 | 0.66 | PLA2G7 (0.46) | MMP13MMP3MMP2MMP9MMP1 | |
| SCHEMBL6954462 | 0.66 | MMP3 (0.56) | MMP13MMP3MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | claimed |
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |