SCHEMBL7219260

SCHEMBL7219260

CC(C(=O)NC(C)(C#N)C(C)C)c1ccc(Cl)cc1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ANO1 Q5XXA6 1/20 0.42
FFAR2 O15552 6/20 0.42
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
CYP2C9 P11712 1/20 0.36
KEAP1 Q14145 1/20 0.36
ACKR3 P25106 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8106282 0.86 CTSK (0.40)
SCHEMBL7215950 0.84 UTS2R (0.41) ANO1FFAR2HDAC4HDAC7HDAC5
SCHEMBL7214349 0.79 POLB (0.47) ANO1
SCHEMBL8650991 0.77 CTSL (0.36) ANO1KEAP1
SCHEMBL8104975 0.77 FFAR2 (0.44) FFAR2HDAC4HDAC7HDAC5ACKR3
SCHEMBL7638474 0.77 FFAR2 (0.44) FFAR2HDAC4HDAC7HDAC5ACKR3
SCHEMBL7220058 0.77 FFAR2 (0.44) FFAR2HDAC4HDAC7HDAC5ACKR3
SCHEMBL7220666 0.76 L3MBTL1 (0.57) ANO1KEAP1
SCHEMBL7220927 0.75 FFAR2 (0.40) FFAR2HDAC4HDAC7HDAC5CYP2C9
SCHEMBL7638122 0.74 FFAR2 (0.42) FFAR2HDAC4HDAC7HDAC5CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6504046-B1 Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-01-07 US disclosed
EP-1092705-A1 PROCESS FOR THE PREPARATION OF AMIDES IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed