Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
| ▸ | EPOR | P19235 | 3/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218411 | 0.88 | CPB2 (0.36) | CPB2GSRFOLH1RNPEPEPOR | |
| SCHEMBL8821909 | 0.87 | CPB2 (0.38) | CPB2GSRFOLH1RNPEPEPOR | |
| SCHEMBL7225462 | 0.84 | CPB2 (0.38) | CPB2GSRFOLH1RNPEPEPOR | |
| SCHEMBL7219138 | 0.79 | EPOR (0.38) | EPOR | |
| SCHEMBL8714819 | 0.76 | CPB2 (0.43) | CPB2GSRFOLH1RNPEP | |
| SCHEMBL8716301 | 0.76 | CPB2 (0.35) | CPB2GSRRNPEP | |
| SCHEMBL7226730 | 0.76 | CPB2 (0.38) | CPB2GSRFOLH1RNPEPEPOR | |
| SCHEMBL8712693 | 0.71 | CPB2 (0.37) | CPB2GSRFOLH1RNPEPEPOR | |
| SCHEMBL7912070 | 0.71 | NOS2 (0.39) | GSR | |
| SCHEMBL8716233 | 0.69 | RNPEP (0.40) | CPB2GSRFOLH1RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |