Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221460 | 0.80 | KMT2A (0.40) | MEN1KMT2ATAAR1SLC6A9PTGDR2 | |
| SCHEMBL7216732 | 0.77 | MAPKAPK2 (0.33) | MEN1KMT2ATAAR1MAPK14SLC6A9 | |
| SCHEMBL7221128 | 0.74 | MEN1 (0.36) | MEN1KMT2ATAAR1SLC6A9 | |
| SCHEMBL7221098 | 0.71 | TAAR1 (0.39) | MEN1KMT2ATAAR1MAPK14SLC6A9 | |
| SCHEMBL7216749 | 0.71 | LOXL2 (0.38) | MAPK14SLC6A3 | |
| SCHEMBL2789136 | 0.69 | LTA4H (0.42) | MEN1KMT2ATAAR1MAPK14SLC6A9 | |
| SCHEMBL7220974 | 0.69 | DPP4 (0.38) | TAAR1MAPK14SLC6A3 | |
| SCHEMBL7221014 | 0.69 | KCNH3 (0.40) | MEN1KMT2AKCNH3 | |
| SCHEMBL7214541 | 0.67 | USP2 (0.39) | MEN1KMT2ATAAR1MAPK14SLC6A2 | |
| SCHEMBL8919343 | 0.65 | USP2 (0.39) | MEN1KMT2ATAAR1MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |