Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216732 | 0.72 | MAPKAPK2 (0.33) | KMT2AMEN1 | |
| SCHEMBL7221460 | 0.70 | KMT2A (0.40) | L3MBTL1RAB9AKMT2AHSD17B10MEN1 | |
| SCHEMBL7220960 | 0.69 | MEN1 (0.35) | KCNH3KMT2AMEN1 | |
| SCHEMBL2237397 | 0.66 | KMT2A (0.71) | KCNH3ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL7216749 | 0.65 | LOXL2 (0.38) | RAB9A | |
| SCHEMBL7221128 | 0.65 | MEN1 (0.36) | L3MBTL1RAB9AKMT2AMEN1 | |
| SCHEMBL7216865 | 0.64 | ACHE (0.43) | LMNAL3MBTL1KMT2AMEN1TSHR | |
| SCHEMBL7216927 | 0.64 | KDM4E (0.49) | ALDH1A1KDM4ELMNAATMSMN1; SMN2 | |
| SCHEMBL7215286 | 0.63 | KMT2A (0.46) | ALDH1A1KDM4EKMT2APKMMEN1 | |
| SCHEMBL2789136 | 0.63 | LTA4H (0.42) | RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |