Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21328440 | 0.83 | CYP1A2 (0.59) | HSD17B10ACHECYP1A2RAB9AKMT2A | |
| SCHEMBL7223998 | 0.79 | NOTUM (0.49) | HSD17B10CYP1A2POLBRAB9AL3MBTL1 | |
| SCHEMBL21102240 | 0.79 | HSD17B10 (0.41) | HSD17B10ACHECYP1A2POLBRAB9A | |
| SCHEMBL11864053 | 0.77 | ALDH1A1 (0.51) | HSD17B10CYP1A2POLBRAB9AL3MBTL1 | |
| SCHEMBL29297658 | 0.77 | RAB9A (0.57) | HSD17B10CYP1A2POLBRAB9AL3MBTL1 | |
| SCHEMBL14507031 | 0.76 | GABRA1 (0.41) | HSD17B10ACHEGABRA1GABRB2L3MBTL1 | |
| SCHEMBL30421739 | 0.76 | HTR7 (0.44) | HSD17B10CYP1A2POLBRAB9AL3MBTL1 | |
| SCHEMBL7417947 | 0.75 | MTNR1A (0.55) | HSD17B10POLBRAB9ALMNAHTT | |
| SCHEMBL9661198 | 0.73 | HSD17B10 (0.74) | HSD17B10CYP1A2POLBRAB9AL3MBTL1 | |
| SCHEMBL16844673 | 0.72 | PTGS2 (0.51) | ACHEGABRA1GABRB2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552226-B1 | Rapid; low temperature; one pot synthesis; reduced catalytic quantities of such as lewis acid and tertiary amine; entiomerically pure products | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-04-22 | — | — | US | disclosed |
| WO-2002026683-A1 | TANDEM ACYL-CLAISEN REARRANGEMENT IN THE PREPARATION OF CHIRAL PRODUCTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-04 | — | — | WO | disclosed |
| US-6359174-B1 | REACTING ALLYL REACTANT WITH ACID CHLORIDE IN PRESENCE OF LEWIS ACID CATALYST | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-03-19 | — | — | US | disclosed |