Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230427 | 0.88 | CNR1 (0.36) | SLC6A2SLC6A4SLC6A3HTR3EHTR3B | |
| SCHEMBL7223552 | 0.88 | NPC1 (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7232879 | 0.86 | CHRM4 (0.41) | KDM1AHCRTR1HCRTR2HTR3EHTR3B | |
| SCHEMBL7224821 | 0.84 | CTSK (0.37) | HCRTR1HCRTR2CTSKCTSCSLC6A2 | |
| SCHEMBL7231066 | 0.82 | KDM4E (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7225526 | 0.82 | DGAT1 (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7230824 | 0.80 | CHRNB2 (0.39) | HCRTR1HCRTR2SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL7233563 | 0.79 | HCRTR1 (0.40) | HCRTR1HCRTR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7075331 | 0.78 | USP30 (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7059395 | 0.77 | CHRNA7 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |