Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224821 | 0.89 | CTSK (0.37) | CHRNB2CHRNA4HCRTR1HCRTR2SLC6A3 | |
| SCHEMBL7223552 | 0.88 | NPC1 (0.38) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7233563 | 0.87 | HCRTR1 (0.40) | KMT2AHCRTR1HCRTR2SLC6A3NPC1 | |
| SCHEMBL7230427 | 0.84 | CNR1 (0.36) | CHRNB2CHRNA4CNR2KMT2ASLC6A3 | |
| SCHEMBL7224140 | 0.82 | HDAC1 (0.47) | CHRNB2CHRNA4NPC1RAB9AGRM5 | |
| SCHEMBL24976080 | 0.80 | CNR2 (0.48) | CNR2KMT2ARAB9AGRM5 | |
| SCHEMBL7223372 | 0.80 | RIPK1 (0.36) | CHRNB2CHRNA4HCRTR1HCRTR2SLC6A3 | |
| SCHEMBL7231066 | 0.80 | KDM4E (0.39) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL7232879 | 0.79 | CHRM4 (0.41) | CNR2HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL7232673 | 0.78 | MAPK11 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |