Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230824 | 0.87 | CHRNB2 (0.39) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL7224821 | 0.87 | CTSK (0.37) | HCRTR1HCRTR2FAAHGPR52SLC6A2 | |
| SCHEMBL7223552 | 0.86 | NPC1 (0.38) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL7230675 | 0.84 | HDAC1 (0.49) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL7232879 | 0.83 | CHRM4 (0.41) | HCRTR1HCRTR2NPC1RAB9AFAAH | |
| SCHEMBL7232229 | 0.80 | HDAC6 (0.50) | NPC1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7233259 | 0.80 | HDAC3 (0.49) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL7223372 | 0.79 | RIPK1 (0.36) | HCRTR1HCRTR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7231066 | 0.79 | KDM4E (0.39) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL7230427 | 0.79 | CNR1 (0.36) | NPC1RAB9AKMT2AMEN1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |