Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232046 | 0.91 | ALDH1A1 (0.39) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL7231360 | 0.89 | SLC6A3 (0.39) | SLC6A4SLC6A3SLC6A2ABL1CHRNB2 | |
| SCHEMBL7234091 | 0.89 | SLC6A4 (0.41) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL7233162 | 0.88 | HTR3E (0.38) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL7231538 | 0.88 | SLC6A3 (0.42) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL7225309 | 0.86 | PDE4A (0.35) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL7231983 | 0.85 | SLC6A3 (0.37) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL7226375 | 0.85 | MAPT (0.48) | SLC6A4SLC6A3SLC6A2GRM5ALDH1A1 | |
| SCHEMBL7225396 | 0.83 | SLC6A4 (0.37) | SLC6A4SLC6A3SLC6A2ABL1CHRNB2 | |
| SCHEMBL7234468 | 0.83 | SLC6A3 (0.35) | SLC6A4SLC6A3SLC6A2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |