Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225739 | 0.89 | ALDH1A1 (0.45) | MAPTNPSR1MAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7233832 | 0.88 | SLC6A3 (0.42) | MAPTNPSR1MAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7225481 | 0.87 | NPSR1 (0.45) | MAPTNPSR1MAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7223564 | 0.85 | SLC6A4 (0.39) | MAPTNPSR1MAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7232058 | 0.83 | NPSR1 (0.40) | MAPTNPSR1MAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7127654 | 0.82 | GRM5 (0.47) | SLC6A4SLC6A2SLC6A3GRM5TRPV1 | |
| SCHEMBL7224670 | 0.82 | LMNA (0.43) | MAPTNPSR1MAPK1ALDH1A1SLC6A3 | |
| SCHEMBL7225482 | 0.82 | ALDH1A1 (0.54) | MAPTMAPK1ALDH1A1KDM4EGAA | |
| SCHEMBL7225781 | 0.79 | PTPN11 (0.44) | MAPTALDH1A1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7225045 | 0.79 | SLC6A3 (0.41) | SLC6A4SLC6A2SLC6A3GRM5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |