Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | RHOA | P61586 | 1/20 | 0.52 |
| ▸ | PDE8A | O60658 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224007 | 0.86 | EGFR (0.50) | EGFRSRCKDM4EHSD17B10MEN1 | |
| SCHEMBL13977074 | 0.84 | KDM4E (0.57) | KDM4EHSD17B10HDAC6 | |
| SCHEMBL7217250 | 0.83 | L3MBTL1 (0.49) | L3MBTL1RHOAPDE8APDE4AKDM4E | |
| SCHEMBL7224196 | 0.81 | CDH1 (0.52) | L3MBTL1RHOAPDE8APDE4AKDM4E | |
| SCHEMBL9728470 | 0.77 | RAB9A (0.68) | KDM4EHSD17B10RXFP1MEN1KMT2A | |
| SCHEMBL9728142 | 0.73 | MEN1 (0.56) | L3MBTL1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL7222282 | 0.72 | AKR1C3 (0.71) | L3MBTL1RHOAKDM4ECDC25BMEN1 | |
| 3-Phenylamino Benzoic Acid SCHEMBL4345076 | 0.70 | RHOA (0.77) | L3MBTL1RHOAKDM4EHSD17B10CDC25B | |
| SCHEMBL7223862 | 0.69 | KDM4E (0.46) | EGFRSRCKDM4EHSD17B10RXFP1 | |
| SCHEMBL30633056 | 0.69 | RHOA (0.93) | L3MBTL1RHOAKDM4ECDC25BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | claimed |
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |