Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225481 | 0.90 | NPSR1 (0.45) | SLC6A3ALDH1A1MAPTMAPK1NPSR1 | |
| SCHEMBL7225739 | 0.89 | ALDH1A1 (0.45) | SLC6A3ALDH1A1MAPTMAPK1NPSR1 | |
| SCHEMBL7233832 | 0.89 | SLC6A3 (0.42) | LMNATSHRSLC6A3ALDH1A1MAPT | |
| SCHEMBL7230399 | 0.85 | MAPT (0.36) | LMNASLC6A3ALDH1A1MAPTMAPK1 | |
| SCHEMBL7125195 | 0.83 | MMP2 (0.36) | ALDH1A1NPSR1SSTR3 | |
| SCHEMBL7225383 | 0.82 | SLC6A3 (0.41) | LMNATSHRSLC6A3SMN1; SMN2KCNH2 | |
| SCHEMBL7226375 | 0.82 | MAPT (0.48) | LMNATSHRSLC6A3ALDH1A1MAPT | |
| SCHEMBL7121780 | 0.82 | SLC6A3 (0.46) | SLC6A3SMN1; SMN2KCNH2SSTR3 | |
| SCHEMBL7072340 | 0.81 | PTPN1 (0.46) | LMNASLC6A3ALDH1A1MAPTNPSR1 | |
| SCHEMBL7232058 | 0.81 | NPSR1 (0.40) | SLC6A3ALDH1A1MAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |