Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232058 | 0.88 | NPSR1 (0.40) | MAPTMAPK1NPSR1SLC6A3ALDH1A1 | |
| SCHEMBL7225481 | 0.86 | NPSR1 (0.45) | MAPTMAPK1NPSR1SLC6A3ALDH1A1 | |
| SCHEMBL7224670 | 0.85 | LMNA (0.43) | MAPTMAPK1NPSR1SLC6A3HPGD | |
| SCHEMBL7224405 | 0.83 | SLC6A3 (0.36) | SLC6A3HPGDKDM1ASLC6A2SLC6A4 | |
| SCHEMBL7233832 | 0.83 | SLC6A3 (0.42) | MAPTMAPK1NPSR1SLC6A3ALDH1A1 | |
| SCHEMBL7125236 | 0.80 | PARP10 (0.47) | — | |
| SCHEMBL7072612 | 0.80 | RAB9A (0.49) | MAPTMAPK1NPSR1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7070829 | 0.79 | RAB9A (0.48) | MAPTMAPK1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL7225739 | 0.79 | ALDH1A1 (0.45) | MAPTMAPK1NPSR1SLC6A3ALDH1A1 | |
| SCHEMBL7226375 | 0.79 | MAPT (0.48) | MAPTMAPK1NPSR1SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |