Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230688 | 0.85 | AKT1 (0.44) | CHRNA7CHRNB2CHRNA4L3MBTL1AKT1 | |
| SCHEMBL7224879 | 0.85 | AKT1 (0.39) | CHRNA7CHRNB2CHRNA4FAAHAKT1 | |
| SCHEMBL7231889 | 0.84 | FAAH (0.49) | FAAH | |
| SCHEMBL7226398 | 0.84 | AKT1 (0.34) | CHRNA7CHRNB2CHRNA4L3MBTL1AKT1 | |
| SCHEMBL7232903 | 0.83 | SLC6A3 (0.38) | CHRNA7CHRNB2CHRNA4AKT1 | |
| SCHEMBL7232737 | 0.83 | MMP13 (0.49) | CHRNA7CHRNB2CHRNA4L3MBTL1AKT1 | |
| SCHEMBL7226388 | 0.83 | AKT1 (0.37) | CHRNA7CHRNB2CHRNA4L3MBTL1AKT1 | |
| SCHEMBL7074460 | 0.83 | NPC1 (0.44) | CHRNA7CHRNB2CHRNA4L3MBTL1 | |
| SCHEMBL375394 | 0.83 | NPC1 (0.44) | CHRNA7CHRNB2CHRNA4L3MBTL1 | |
| SCHEMBL7224807 | 0.82 | MGAM (0.35) | CHRNA7CHRNB2CHRNA4HSP90AA1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |