Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224879 | 0.88 | AKT1 (0.39) | AKT1ALDH1A1MAPTSLC6A4SLC6A3 | |
| SCHEMBL7232737 | 0.85 | MMP13 (0.49) | AKT1NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7224822 | 0.85 | CHRNA7 (0.47) | AKT1L3MBTL1GRM5CHRNB2CHRNA7 | |
| SCHEMBL7234270 | 0.84 | NPC1 (0.40) | AKT1NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7224388 | 0.82 | NPC1 (0.46) | AKT1NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7225482 | 0.82 | ALDH1A1 (0.54) | NPC1RAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7224672 | 0.82 | S1PR4 (0.49) | ALDH1A1KDM4ESMN1; SMN2MAPTLMNA | |
| SCHEMBL7232072 | 0.82 | HTT (0.48) | NPC1RAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7226254 | 0.81 | NPC1 (0.59) | AKT1NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7223707 | 0.81 | NPC1 (0.38) | AKT1NPC1RAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |