Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
| ▸ | USP10 | Q14694 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRND | Q07001 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224358 | 0.82 | SLC6A3 (0.36) | CHRNA7SLC6A3SLC6A2SLC6A4CHRNA1 | |
| SCHEMBL7225927 | 0.81 | CHRNA7 (0.35) | CHRNA7HTR3A | |
| SCHEMBL7223174 | 0.81 | CHRNA7 (0.33) | CHRNA7CHRNB4CHRNA3HTR3A | |
| SCHEMBL7231950 | 0.81 | TAS1R3 (0.36) | CHRNA7SLC6A3SLC6A2SLC6A4CHRNA1 | |
| SCHEMBL7231186 | 0.80 | CHRNA7 (0.33) | CHRNA7SLC6A3SLC6A2SLC6A4CHRNA1 | |
| SCHEMBL7223431 | 0.80 | HTR3E (0.33) | CHRNA7HTR3A | |
| SCHEMBL7230577 | 0.80 | SLC6A3 (0.33) | CHRNA7SLC6A3SLC6A2SLC6A4HTR3A | |
| SCHEMBL7232807 | 0.80 | CHRNA7 (0.41) | CHRNA7SLC6A3HTR3A | |
| SCHEMBL7224323 | 0.79 | MEN1 (0.38) | — | |
| SCHEMBL7231162 | 0.79 | NPC1 (0.43) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |