Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232031 | 0.89 | PTPN11 (0.43) | PTPN11SMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL7230851 | 0.85 | CHRNA7 (0.35) | SMN1; SMN2ALDH1A1LMNAKMT2AGFER | |
| SCHEMBL7224259 | 0.83 | SLC6A3 (0.39) | SMN1; SMN2ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7232514 | 0.83 | ACKR3 (0.33) | — | |
| SCHEMBL7072612 | 0.82 | RAB9A (0.49) | SMN1; SMN2ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7231968 | 0.82 | ALDH1A1 (0.42) | PTPN11SMN1; SMN2ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL7070829 | 0.81 | RAB9A (0.48) | SMN1; SMN2ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7234113 | 0.79 | PTPN11 (0.41) | PTPN11SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7225781 | 0.78 | PTPN11 (0.44) | PTPN11SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7230399 | 0.78 | MAPT (0.36) | SMN1; SMN2ALDH1A1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |