SCHEMBL7227192

SCHEMBL7227192

COc1cc(Cl)nc(C(=O)NS(=O)(=O)c2ccccc2OC(F)(F)F)c1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.51
ALPL P05186 5/20 0.43
SLC22A12 Q96S37 3/20 0.42
PTGER4 P35408 1/20 0.42
SLC40A1 Q9NP59 1/20 0.40
AXL P30530 1/20 0.39
CLK1 P49759 1/20 0.39
IDH1 O75874 1/20 0.38
KCNK3 O14649 1/20 0.38
KCNK9 Q9NPC2 1/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
MRGPRX1 Q96LB2 1/20 0.38
ALKBH2 Q6NS38 1/20 0.37
ALKBH3 Q96Q83 1/20 0.37
FTO Q9C0B1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227358 0.88 ALPL (0.44) FBP1ALPLSLC22A12PTGER4SLC40A1
SCHEMBL7226876 0.84 FLT1 (0.49) ALKBH2ALKBH3
SCHEMBL7236902 0.83 GCK (0.40) ALKBH2ALKBH3
SCHEMBL7235311 0.83 SLC40A1 (0.47) FBP1ALPLSLC22A12PTGER4SLC40A1
SCHEMBL7227108 0.82 FBP1 (0.49) FBP1ALPLSLC22A12PTGER4SLC40A1
SCHEMBL7227903 0.81 FBP1 (0.46) FBP1ALPLSLC22A12PTGER4SLC40A1
SCHEMBL7226908 0.81 KMT2A (0.44) SLC40A1
SCHEMBL7227157 0.80 ALDH1A1 (0.38) ALKBH2ALKBH3
SCHEMBL7233649 0.80 CCR4 (0.47)
SCHEMBL7235392 0.78 ALKBH2 (0.35) FBP1ALKBH2ALKBH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610853-B1 N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide KUREHA KAGAKU KOGYO K.K. (JP) 2003-08-26 US disclosed
EP-1069112-A1 N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-01-17 EP disclosed