Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228253 | 0.85 | CYP1A2 (0.34) | ALDH1A1TP53LMNAMAPTTDP1 | |
| SCHEMBL7222699 | 0.69 | NOS3 (0.36) | NOS3NOS2 | |
| SCHEMBL7228451 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTTDP1KDM4E | |
| SCHEMBL7228444 | 0.68 | PDE7A (0.39) | ALDH1A1LMNAMAPTCYP3A4TSHR | |
| SCHEMBL3192684 | 0.65 | ALDH1A1 (0.62) | ALDH1A1TP53TDP1CYP3A4TSHR | |
| SCHEMBL7226711 | 0.64 | TSHR (0.33) | ALDH1A1TDP1CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL29674727 | 0.63 | NOS2 (0.50) | ALDH1A1TP53LMNAMAPTTDP1 | |
| SCHEMBL204345 | 0.63 | NOS2 (0.50) | ALDH1A1TP53LMNAMAPTTDP1 | |
| SCHEMBL7228254 | 0.62 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTTDP1PKM | |
| SCHEMBL377032 | 0.62 | TSHR (0.55) | ALDH1A1TP53MAPTTDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583138-B1 | Mediators or antagonists of the effects of histamine, leukotriene and the like; heterocyclic ring condensed benzothiazine compounds; inhibit the activation of the tyrosine kinase of 72 kDa | EISAI CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1057830-A1 | HETEROCYCLE-FUSED BENZOTHIAZINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |