Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | ADH5 | P11766 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316619 | 0.87 | ITGB3 (0.51) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL6606264 | 0.85 | ITGB3 (0.58) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL8893341 | 0.76 | ITGB3 (0.56) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL7461633 | 0.73 | ITGB3 (0.51) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL12603742 | 0.72 | ADH5 (0.56) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL8858128 | 0.71 | ITGB3 (0.46) | ITGB3ITGA2BF10ALDH1A1PLA2G2A | |
| SCHEMBL7456647 | 0.70 | ITGB3 (0.49) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL7068870 | 0.70 | THRB (0.47) | GRM2 | |
| SCHEMBL8892944 | 0.70 | ITGB3 (0.49) | ITGB3ITGA2BF10ADH5ALDH1A1 | |
| SCHEMBL7463090 | 0.70 | ITGB3 (0.53) | ITGB3ITGA2BF10ADH5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |