Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231670 | 0.84 | GABRA1 (0.53) | SMN1; SMN2ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL1691295 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL7240406 | 0.73 | ALOX5 (0.43) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL7235014 | 0.72 | RAB9A (0.53) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL5630676 | 0.71 | GABRA1 (0.72) | SMN1; SMN2ALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL7233487 | 0.71 | EGFR (0.48) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL7241464 | 0.71 | CYP11B1 (0.42) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL18136531 | 0.70 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL7230585 | 0.70 | GRIN1 (0.45) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 | |
| SCHEMBL7240481 | 0.69 | ALOX5 (0.48) | SMN1; SMN2ALDH1A1KDM4ERAB9AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552037-B2 | An imidazo(1,2-a)Pyridine compound useful for altering the signal-transducing activity of gamma-aminobuytric acid receptor | NEUROGEN CORPORATION | 2003-04-22 | — | — | US | claimed |
| US-20020032200-A1 | 2-Substituted imidazo[1,2-A]pyridine derivatives | NEUROGEN CORPORATION | 2002-03-14 | — | — | US | claimed |
| US-6552037-B2 | An imidazo(1,2-a)Pyridine compound useful for altering the signal-transducing activity of gamma-aminobuytric acid receptor | NEUROGEN CORPORATION | 2003-04-22 | — | — | US | disclosed |
| US-20020032200-A1 | 2-Substituted imidazo[1,2-A]pyridine derivatives | NEUROGEN CORPORATION | 2002-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032200-A1 | 2-Substituted imidazo[1,2-A]pyridine derivatives | GABBR2, GABRP, GABBR1 | SMN1; SMN2 672/4885ALDH1A1 403/4885KDM4E 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.