Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078753 | 1.00 | HPGD (0.40) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7230533 | 1.00 | HPGD (0.40) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL354098 | 0.78 | ACHE (0.53) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL29410363 | 0.78 | ACHE (0.53) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL354099 | 0.78 | ACHE (0.53) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5970427 | 0.78 | ACHE (0.53) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3842551 | 0.74 | METAP1 (0.41) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL31137726 | 0.74 | SIGMAR1 (0.43) | ACHENOS3NOS2HTR2A | |
| SCHEMBL5263075 | 0.74 | HRH1 (0.39) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5263072 | 0.74 | HRH1 (0.39) | HPGDL3MBTL1ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531617-B2 | Adding an acid halide to a solution of aluminum chloride to form an alkylcarbonyloxy chromanone, which is further reacted with lithium (hydro)peroxide at a temperature of < 0 degrees C | MERCK & CO., INC. | 2003-03-11 | — | — | US | disclosed |
| US-20020095047-A1 | Process for preparing hydroxychomanones and CIS-aminochromanols | MERCK & CO., INC. | 2002-07-18 | — | — | US | disclosed |
| US-6384244-B2 | HYDROGENATING OXIME IN PRESENCE OF A CATALYST AND AN ACID; USEFUL AS CHEMICAL INTERMEDIATES IN PRODUCTION OF HIV PROTEASE INHIBITORS | MERCK & CO., INC. | 2002-05-07 | — | — | US | disclosed |
| US-20010056193-A1 | Process for preparing cis- aminochromanols | MERCK & CO., INC. | 2001-12-27 | — | — | US | disclosed |
| WO-2001087873-A1 | PROCESS FOR PREPARING CIS-AMINOCHROMANOLS | MERCK & CO., INC. (US) | 2001-11-22 | — | — | WO | disclosed |
| US-6057479-A | MULTISTAGE REACTION OF HYDROXY INDANONE WITH AMINE TO FORM IMINE, HEATING AND HYDROGENATION | NIPPON STEEL CHEMICAL CO., LTD. (JP) | 2000-05-02 | — | — | US | disclosed |
| EP-0874059-A1 | PROCESSES FOR PRODUCING INDANE DERIVATIVES | NIPPON STEEL CHEMICAL CO., LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |
| EP-0874059-A2 | PROCESSES FOR PRODUCING INDANE DERIVATIVES | NIPPON STEEL CHEMICAL CO., LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056193-A1 | Process for preparing cis- aminochromanols | SRR, GRHPR, SPR | HPGD 416/4885L3MBTL1 2906/4885ALDH1A1 2636/4885 |
| US-20020095047-A1 | Process for preparing hydroxychomanones and CIS-aminochromanols | HACL2, HAAO, APEH | HPGD 459/4885L3MBTL1 1983/4885ALDH1A1 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.