Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.30 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7247796 | 1.00 | ADRA2A (0.31) | ADRA2AADRA1AMRGPRX1 | |
| SCHEMBL7097676 | 0.93 | ADRA2A (0.34) | ADRA2AADRA1AMRGPRX1 | |
| Maleic Acid SCHEMBL7102529 | 0.91 | TRPV1 (0.32) | — | |
| Fumaric Acid SCHEMBL7102536 | 0.91 | TRPV1 (0.32) | — | |
| SCHEMBL7103690 | 0.83 | BRAF (0.33) | ADRA2AADRA1A | |
| SCHEMBL7102533 | 0.78 | — | — | |
| SCHEMBL7101615 | 0.78 | ADRA2A (0.46) | ADRA2AADRA1A | |
| SCHEMBL7097241 | 0.77 | ADRA2A (0.46) | ADRA2AADRA1A | |
| Fumaric Acid SCHEMBL7102519 | 0.77 | ADRA1A (0.39) | ADRA2AADRA1AMRGPRX1 | |
| Maleic Acid SCHEMBL7102511 | 0.77 | ADRA1A (0.39) | ADRA2AADRA1AMRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503935-B1 | Treating urinary incontinence or retrograde ejaculation | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |