Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.39 |
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 0.38 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.35 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.33 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7102511 | 1.00 | ADRA1A (0.39) | ADRA1AADRA2AKCNH2TRPV1ADRA2B | |
| SCHEMBL7103530 | 0.92 | ADRA1A (0.43) | ADRA1AADRA2ATRPV1ADRA2BADRA2C | |
| Maleic Acid SCHEMBL7102529 | 0.85 | TRPV1 (0.32) | TRPV1 | |
| Fumaric Acid SCHEMBL7102536 | 0.85 | TRPV1 (0.32) | TRPV1 | |
| SCHEMBL7101615 | 0.82 | ADRA2A (0.46) | ADRA1AADRA2AADRA2BADRA2C | |
| SCHEMBL7105127 | 0.77 | ADRA2A (0.48) | ADRA1AADRA2AADRA2BADRA2C | |
| Fumaric Acid SCHEMBL7247808 | 0.77 | ADRA2A (0.31) | ADRA1AADRA2AMRGPRX1 | |
| Maleic Acid SCHEMBL7247796 | 0.77 | ADRA2A (0.31) | ADRA1AADRA2AMRGPRX1 | |
| SCHEMBL7102119 | 0.77 | ADRA1A (0.62) | ADRA1AADRA2A | |
| SCHEMBL7103690 | 0.77 | BRAF (0.33) | ADRA1AADRA2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073850-A1 | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use | ABBOTT LABORATORIES | 2003-04-17 | — | — | US | disclosed |
| EP-1259491-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | Abbott Laboratories (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001060802-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES, AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073850-A1 | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use | ADRA1D, ADRB1, ADRA1A | ADRA1A 3/4885ADRA2A 8/4885KCNH2 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.