Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.68 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15471651 | 1.00 | OPRM1 (0.68) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL15471672 | 0.88 | OPRM1 (0.73) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL16871402 | 0.88 | OPRM1 (0.73) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| Hydrochloric Acid SCHEMBL15121412 | 0.86 | OPRM1 (0.63) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL5177521 | 0.84 | OPRM1 (0.67) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL5014485 | 0.84 | OPRM1 (0.67) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL9918287 | 0.82 | OPRM1 (0.66) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL9918290 | 0.82 | OPRM1 (0.66) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| Tapentadol SCHEMBL16267909 | 0.81 | OPRM1 (1.00) | OPRM1SLC22A1ADRA1AADRB1MIF | |
| SCHEMBL22876032 | 0.81 | OPRM1 (0.64) | OPRM1SLC22A1ADRA1AADRB1MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850198-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-9850198-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-9850198-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| EP-2792668-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2792668-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2666765-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| EP-2666765-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| EP-2666765-A2 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | Grünenthal GmbH (DE) | 2013-11-27 | — | — | EP | disclosed |
| CN-103168025-A | Process for preparing substituted 3- (1-amino-2-methylpentane-3-yl) phenyl compounds | GRUENENTHAL GMBH | 2013-06-19 | — | — | CN | disclosed |
| EP-2582659-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-(1-AMINO-2-METHYLPENTANE-3-YL)PHENYL COMPOUNDS | Grünenthal GmbH (DE) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157390-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-(1-AMINO-2-METHYLPENTANE-3-YL)PHENYL COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011157390-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-(1-AMINO-2-METHYLPENTANE-3-YL)PHENYL COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-22 | — | — | WO | disclosed |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | CYP51A1, CYP3A4, NPEPPS | OPRM1 1144/4885SLC22A1 4864/4885ADRA1A 150/4885 |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | NPEPPS, PNMT, CYP3A4 | OPRM1 709/4885SLC22A1 4867/4885ADRA1A 361/4885 |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | ADRM1, PNMT, ACMSD | OPRM1 137/4885SLC22A1 4657/4885ADRA1A 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.