Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253031 | 0.77 | FFAR1 (0.40) | SLC6A3ALDH1A1MEN1KMT2A | |
| SCHEMBL6801133 | 0.75 | LMNA (0.35) | LMNASLC6A3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7253305 | 0.74 | RAB9A (0.40) | SLC6A3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4721186 | 0.72 | L3MBTL1 (0.48) | LMNASLC6A3ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL3098479 | 0.71 | NPC1 (0.51) | LMNASLC6A3SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7253353 | 0.68 | MEN1 (0.39) | LMNAALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL1711764 | 0.66 | KCNH2 (0.53) | LMNAALDH1A1HPGDSMN1; SMN2PDE10A | |
| SCHEMBL1711836 | 0.66 | SYK (0.48) | HPGDSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL543113 | 0.65 | MAOB (0.54) | LMNAALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL5760005 | 0.64 | PLAU (0.40) | LMNAALDH1A1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |