Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SOD1 | P00441 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804342 | 0.78 | ADAM17 (0.37) | SLC6A3MAPTL3MBTL1FFAR1PPARD | |
| SCHEMBL7263114 | 0.75 | LMNA (0.36) | LMNASLC6A3MAPTPTPN11L3MBTL1 | |
| SCHEMBL6803571 | 0.74 | RAB9A (0.40) | LMNATDP1SOD1MAOBMEN1 | |
| SCHEMBL1758562 | 0.73 | SLC6A3 (0.39) | SLC6A3 | |
| SCHEMBL6804913 | 0.70 | PARP10 (0.56) | MAPTFFAR1ALDH1A1MAOBPARP10 | |
| SCHEMBL6806069 | 0.70 | ADAM17 (0.39) | MAPTL3MBTL1TDP1SOD1FFAR1 | |
| SCHEMBL6804893 | 0.70 | SOD1 (0.42) | LMNAMAPTL3MBTL1TDP1SOD1 | |
| SCHEMBL6806039 | 0.69 | MAPT (0.41) | LMNAMAPTL3MBTL1FFAR1PPARA | |
| SCHEMBL6804575 | 0.69 | FFAR1 (0.42) | SLC6A3MAPTFFAR1ALDH1A1HPGD | |
| SCHEMBL6805550 | 0.69 | SLC22A12 (0.43) | FFAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |