Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187332 | 0.79 | TDO2 (0.38) | SMN1; SMN2ALDH1A1TDP1DPP4PDCD1 | |
| SCHEMBL8384763 | 0.79 | CYP1A2 (0.39) | SMN1; SMN2ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL11650552 | 0.73 | MAPT (0.34) | MAPTHTT | |
| SCHEMBL457404 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2ADRB2ALDH1A1MAPTADORA2A | |
| SCHEMBL10599404 | 0.72 | HSP90AA1 (0.46) | SMN1; SMN2ALDH1A1LMNAMAPTPOLB | |
| SCHEMBL21408573 | 0.72 | KEAP1 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL1774729 | 0.72 | DPP4 (0.36) | SMN1; SMN2ADRB2ALDH1A1LMNAADORA2A | |
| SCHEMBL4600275 | 0.72 | TRPA1 (0.33) | ALDH1A1 | |
| SCHEMBL4056504 | 0.71 | ALDH1A1 (0.41) | ALDH1A1TDP1HSD17B10MAPK1HPGD | |
| SCHEMBL5904052 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2ADRB2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051879-A1 | KNOWN AND NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES USEFUL AS POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2003-06-26 | — | — | WO | disclosed |