Sugi Predict

Sugi Predict / Compounds / SCHEMBL7265277

SCHEMBL7265277

SCHEMBL7265277

CN1C2CCC1(C(=O)c1ccccc1)CC(O)C2

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.39
▸ HTR3E A5X5Y0 1/20 0.38
▸ HTR3B O95264 1/20 0.38
▸ CHRNA7 P36544 1/20 0.38
▸ HTR3A P46098 1/20 0.38
▸ HTR3D Q70Z44 1/20 0.38
▸ HTR3C Q8WXA8 1/20 0.38
▸ CHRM2 P08172 2/20 0.38
▸ CHRM4 P08173 2/20 0.38
▸ CHRM1 P11229 2/20 0.38
▸ CHRM3 P20309 2/20 0.38
▸ PIK3CD O00329 1/20 0.35
▸ CHRM5 P08912 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7281820 0.84 CYP2D6 (0.40) LMNAHTR3EHTR3BHTR3AHTR3D
SCHEMBL2126981 0.84 LMNA (0.46) LMNAHTR3EHTR3BCHRNA7HTR3A
SCHEMBL29601267 0.77 CHRM1 (0.46) LMNACHRM2CHRM4CHRM1CHRM3
SCHEMBL7349981 0.73 LMNA (0.32) LMNACHRM2CHRM1CHRM3
SCHEMBL4188443 0.70 LMNA (0.44) LMNA
SCHEMBL1012742 0.68 MEN1 (0.40) —
SCHEMBL2127479 0.67 KDM4E (0.44) —
SCHEMBL11247347 0.66 HTR3E (0.51) LMNAHTR3EHTR3BCHRNA7HTR3A
SCHEMBL2636272 0.66 KMT2A (0.38) CHRM2
SCHEMBL2727880 0.65 CHRNA7 (0.60) HTR3EHTR3BCHRNA7HTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210069173-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE ALTER DOMUS (US) LLC 2021-03-11 — — US claimed
WO-2019143508-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE CODY LABORATORIES, INC. (US) 2019-07-25 — — WO claimed
US-20190224184-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE ALTER DOMUS (US) LLC 2019-07-25 — — US claimed
US-20190224185-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE CODY LABORATORIES, INC. 2019-07-25 — — US claimed
US-12480131-B2 Tropane alkaloid (TA) producing non-plant host cells, and methods of making and using the same THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2025-11-25 — — US disclosed
US-20240191267-A1 Tropane Alkaloid Transporters and Methods of Making Tropane Alkaloids Using the Same HERCULES CAPITAL, INC., AS AGENT 2024-06-13 — — US disclosed
EP-4314301-A1 TROPANE ALKALOID TRANSPORTERS AND METHODS OF MAKING TROPANE ALKALOIDS USING THE SAME The Board of Trustees of the Leland Stanford Junior University (US) 2024-02-07 — — EP disclosed
WO-2022204283-A1 TROPANE ALKALOID TRANSPORTERS AND METHODS OF MAKING TROPANE ALKALOIDS USING THE SAME THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-09-29 — — WO disclosed
US-20220170026-A1 TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS, AND METHODS OF MAKING AND USING THE SAME HERCULES CAPITAL, INC., AS AGENT 2022-06-02 — — US disclosed
EP-3934765-A1 TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS, AND METHODS OF MAKING AND USING THE SAME The Board Of Trustees Of The Leland Stanford Junior University (US) 2022-01-12 — — EP disclosed
US-20210069173-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE ALTER DOMUS (US) LLC 2021-03-11 — — US disclosed
WO-2020185626-A1 TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS, AND METHODS OF MAKING AND USING THE SAME THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2020-09-17 — — WO disclosed
EP-0111607-B1 TROPYL AND PSEUDOTROPYL ALKYL-BENZOATES AND THEIR USE IN MIGRAINE TREATMENT MERRELL TORAUDE ET COMPAGNIE (FR) 1986-05-21 — — EP disclosed
US-4585866-A Treatment of migraine with substituted tropyl benzoate derivatives MERRELL DOW PHARMACEUTICALS INC. (US) 1986-04-29 — — US disclosed
US-4563465-A ANTISEROTONINE AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1986-01-07 — — US disclosed
US-4486441-A PROPHYLAXIS MERRELL TORAUDE ET COMPAGNIE (FR) 1984-12-04 — — US disclosed
EP-0111608-A1 Pseudotropyl halogeno-benzoates and their use in migraine treatment MERRELL TORAUDE ET COMPAGNIE (FR) 1984-06-27 — — EP disclosed
EP-0112266-A2 Substituted tropyl and pseudotropyl benzoates and their use in migraine treatment MERRELL DOW FRANCE ET CIE (FR) 1984-06-27 — — EP disclosed
EP-0111607-A1 Tropyl and pseudotropyl alkyl-benzoates and their use in migraine treatment MERRELL TORAUDE ET COMPAGNIE (FR) 1984-06-27 — — EP disclosed
EP-0067770-A2 Treatment of migraine with tropyl benzoate derivatives MERRELL DOW FRANCE ET CIE (FR) 1982-12-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190224185-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE CES2, SLC6A3, BCHE LMNA 1855/4885HTR3E 881/4885HTR3B 286/4885
US-20210069173-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE CES2, SLC6A3, BCHE LMNA 1855/4885HTR3E 881/4885HTR3B 286/4885
US-20190224184-A1 PREPARATION OF (-)-COCAINE HYDROCHLORIDE CES2, SLC6A3, BCHE LMNA 1855/4885HTR3E 881/4885HTR3B 286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.