SCHEMBL726544

SCHEMBL726544

O=C(Cl)c1ccc(-c2cccc(C(=O)Cl)c2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.53
HDAC8 Q9BY41 1/20 0.48
RXRA P19793 3/20 0.47
RXRB P28702 3/20 0.47
RXRG P48443 1/20 0.47
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.45
TRIM24 O15164 1/20 0.44
TRIM33 Q9UPN9 1/20 0.44
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
BCL2 P10415 1/20 0.43
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
PRSS1 P07477 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28032601 0.94 KMO (0.59) KMOHDAC8RXRARXRBRXRG
SCHEMBL726087 0.91 KMO (0.56) KMOHDAC8RXRARXRBALDH1A1
SCHEMBL699008 0.89 KMO (0.67) KMOHDAC8RXRARXRBALDH1A1
SCHEMBL30698052 0.89 KMO (0.67) KMOHDAC8RXRARXRBALDH1A1
SCHEMBL28969693 0.88 RXRA (0.53) KMOHDAC8RXRARXRB
Hydrogen Sulfide SCHEMBL27896825 0.88 KMO (0.64) KMOHDAC8RXRARXRBALDH1A1
SCHEMBL244674 0.86 DHODH (0.54) KMOHDAC8RXRARXRBRXRG
SCHEMBL7789337 0.84 ALDH1A1 (0.55) HDAC8ALDH1A1TSHR
SCHEMBL207988 0.82 AURKA (0.50) KMOHDAC8RXRARXRBALDH1A1
SCHEMBL14153043 0.82 ESR2 (0.58) RXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120305484-A1 Thermally Rearranged (TR) Polymers as Membranes for Ethanol Dehydration BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-12-06 US claimed
WO-2012166153-A1 THERMALLY REARRANGED (TR) POLYMERS AS MEMBRANES FOR ETHANOL DEHYDRATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS (US) 2012-12-06 WO claimed
US-8309655-B2 Methods for the preparation of a poly(arylene ether) polysiloxane multiblock copolymer, multiblock copolymers produced thereby, and associated compositions and articles SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-11-13 US claimed
EP-2516501-A1 METHODS FOR THE PREPARATION OF A POLY(ARYLENE ETHER) POLYSILOXANE MULTIBLOCK COPOLYMER SABIC Innovative Plastics IP B.V. (NL) 2012-10-31 EP claimed
WO-2011077297-A1 METHODS FOR THE PREPARATION OF A POLY(ARYLENE ETHER) POLYSILOXANE MULTIBLOCK COPOLYMER SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2011-06-30 WO claimed
US-20110152471-A1 METHODS FOR THE PREPARATION OF A POLY(ARYLENE ETHER) POLYSILOXANE MULTIBLOCK COPOLYMER, MULTIBLOCK COPOLYMERS PRODUCED THEREBY, AND ASSOCIATED COMPOSITIONS AND ARTICLES SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2011-06-23 US claimed
EP-0517943-A1 Copolyestercarbonate polymers derived from diaryl dicarboxylic acids and their derivatives and blends thereof THE DOW CHEMICAL COMPANY (US) 1992-12-16 EP claimed
US-5045610-A Thermoplastic Molding Materials THE DOW CHEMICAL COMPANY (US) 1991-09-03 US claimed
CN-109476913-B Composition for forming release layer 日产化学株式会社 2022-03-01 CN disclosed
EP-2588656-B1 POLYAMIDE-POLY(ARYLENE ETHER) FIBER AND METHOD FOR ITS PREPARATION SABIC GLOBAL TECHNOLOGIES BV (NL) 2019-01-09 EP disclosed
US-10113055-B2 Article comprising poly(phenylene ether)-polysiloxane copolymer composition SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2018-10-30 US disclosed
EP-2516501-B1 METHODS FOR THE PREPARATION OF A POLY(ARYLENE ETHER) POLYSILOXANE MULTIBLOCK COPOLYMER SABIC GLOBAL TECHNOLOGIES BV (NL) 2017-11-15 EP disclosed
EP-3006610-B1 ORGANIC RESIN NON-CRIMPED STAPLE FIBER TEIJIN LTD (JP) 2017-07-19 EP disclosed
EP-3140351-A1 ARTICLE COMPRISING POLY (PHENYLENE ETHER)-POLYSILOXANE COPOLYMER COMPOSITION SABIC Global Technologies B.V. (NL) 2017-03-15 EP disclosed
EP-0517943-A1 Copolyestercarbonate polymers derived from diaryl dicarboxylic acids and their derivatives and blends thereof THE DOW CHEMICAL COMPANY (US) 1992-12-16 EP disclosed
US-5075392-A Non-phase-separated block copolymer THE DOW CHEMICAL COMPANY (US) 1991-12-24 US disclosed
US-5045610-A Thermoplastic Molding Materials THE DOW CHEMICAL COMPANY (US) 1991-09-03 US disclosed
EP-0388803-A2 Thermoplastic compositions containing polybenzoxazole; polybenzothiazole and polybenzimidazole moieties and process for making shaped articles therefrom THE DOW CHEMICAL COMPANY (US) 1990-09-26 EP disclosed
US-4226949-A N-ALKYL POLYAMIDE, DEALKYLATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-10-07 US disclosed
US-4178419-A DEALKYLATION OF N,N'-DIALKYL AROMATIC POLYAMIDES TO FORM AROMATIC POLYAMIDE FOAMS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1979-12-11 US disclosed