Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 3/20 | 0.52 |
| ▸ | RXRB | P28702 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726087 | 0.98 | KMO (0.56) | KMOHDAC8RXRARXRBALDH1A1 | |
| SCHEMBL699008 | 0.96 | KMO (0.67) | KMOHDAC8RXRARXRBALDH1A1 | |
| SCHEMBL30698052 | 0.96 | KMO (0.67) | KMOHDAC8RXRARXRBALDH1A1 | |
| SCHEMBL726544 | 0.94 | KMO (0.53) | KMOHDAC8RXRARXRBALDH1A1 | |
| Hydrogen Sulfide SCHEMBL27896825 | 0.94 | KMO (0.64) | KMOHDAC8RXRARXRBALDH1A1 | |
| SCHEMBL28969693 | 0.90 | RXRA (0.53) | KMOHDAC8RXRARXRBKAT6A | |
| SCHEMBL207988 | 0.88 | AURKA (0.50) | KMOHDAC8RXRARXRBALDH1A1 | |
| SCHEMBL244674 | 0.88 | DHODH (0.54) | KMOHDAC8RXRARXRBLMNA | |
| SCHEMBL27510 | 0.85 | ALDH1A1 (0.59) | KMOHDAC8ALDH1A1TSHR | |
| SCHEMBL9230737 | 0.85 | KMO (0.48) | KMOHDAC8RXRARXRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440528-A | Fourth Ring Bu Luomo structural domain inhibitor | 艾伯维公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105026403-B | Tetracyclic Bromodomain Inhibitors | 艾伯维公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-105026403-A | Tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | disclosed |