Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.43 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769892 | 0.94 | PPID (0.42) | CTSK | |
| SCHEMBL7274083 | 0.84 | REN (0.61) | CTSKRENMMP2CAPN1CTSL | |
| SCHEMBL7883345 | 0.80 | SMN1; SMN2 (0.45) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6900424 | 0.80 | PPID (0.50) | CTSKBIRC2 | |
| SCHEMBL7278916 | 0.79 | RAB9A (0.42) | — | |
| SCHEMBL7278909 | 0.79 | RAB9A (0.42) | — | |
| SCHEMBL7770030 | 0.79 | KCNA5 (0.40) | CTSKCTSSCTSLCTSB | |
| SCHEMBL9830039 | 0.78 | ALDH1A1 (0.58) | — | |
| SCHEMBL30493601 | 0.78 | ALDH1A1 (0.58) | RENMMP2MMP9MMP8PTPN1 | |
| SCHEMBL14932683 | 0.78 | ALDH1A1 (0.58) | RENMMP2MMP9MMP8PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |